Endocrine Abstracts

Background: Paltusotine is an investigational oral, once-daily, small molecule somatostatin receptor type 2 agonist in development for the treatment of acromegaly and carcinoid syndrome associated with neuroendocrine tumors.Methods: This multicenter, open-label, phase 1 study enrolled participants with mild, moderate, and severe hepatic impairment based on Child-Pugh classification and matched healthy participants. A single 20-mg oral dose of paltusotine...

Background: PCOS is characterised by increased production of ovarian and adrenal androgens. Obesity is closely connected to excess androgens and to the disruption of hormone circadian rhythmicity. To date, it is not clear whether hyperandrogenism in PCOS, complicated or not by obesity, is associated with androgen rhythm dysregulation.Aim: To investigate androgen diurnal rhythmicity and overall daily androgen exposure by measuring testosterone(T), androst...

Osteoporosis causes bone fragility usually affecting the elderly. Genetic susceptibility plays a crucial role in determining the risk of fragility fractures and is involved in early-onset osteoporosis. When fragility fractures or low bone mineral density (BMD) occur in young adults without evident secondary osteoporosis, an underlying monogenetic bone disease should be assessed. The list of genes related to low BMD and their mutations is increasing. Nevertheless, little is kno...

Objective: For women with polycystic ovary syndrome (PCOS) weight gain and obesity exacerbate insulin resistance and increase the risk of type 2 diabetes and cardiometabolic diseases. The PCOS Phenotype in Unselected Populations (P-PUP) study includes individual participant data (IPD) from eleven well characterised, multiethnic and unselected populations globally. The aim of this study was to assess risk of obesity in women with and without PCOS according to ethnicity and age....

Background: Psychopathological distress is a significant burden in acromegaly, mostly in terms of depression and anxiety. Patients are also reported to experience an impairment in cognitive performance, yet literature is highly heterogeneous.M&M: We conducted a cross-sectional study recruiting 44 acromegalic patients (59% females, 29.5% with active disease, 70.5% controlled/in remission) referring to our tertiary center between 2011 and 2023 and 40 h...

Background: In the last few decades, the association between pituitary disorders and cardiovascular disease has been demonstrated. Furthermore, the importance of gender as a non-modifiable risk of factor is increasingly emerging.Methods: We retrospectively analyzed data of 112 patients diagnosed with nonfunctioning pituitary tumor (NFPT) attending the outpatient clinic at our tertiary center. In this study we report only preliminary data of the retrospec...

Introduction and Objectives of the Study: Combined oral contraceptives (COCs) are frequently prescribed for fertility control, however sexual dysfunction has been reported as a common side effect. In 2020, a novel progestin-only pill containing Drospirenone (DRSP) was approved as an oral contraceptive. To date, here is a notable dearth of data on the impact of DRSP on sexual function and impact on hormones, particularly regarding steroids. This study aims to investigate the po...

Background: primary empty sella (ES) represents a frequent finding (up to 35% of the general population). According to the literature, the prevalence of hypopituitarism in ES ranges between 19-52%. Data on the natural history of ES over a long time, especially in incidental ES, are still lacking and the management can be challenging.Objective: our primary aim was to assess in a large cohort of patients with ES the prevalence and determinants of hypopitui...

Background: Metyrapone, osilodrostat, and ketoconazole are steroidogenesis inhibitors used as second-line treatment in endogenous Cushing’s syndrome (CS). However, a direct comparison of these three drmgs is missing.Objective: To compare the efficacy of the three drmgs after short-term therapy (≤12 weeks) for CS.Methods: Multicenter, real-life retrospective study involving 20 centers worldwide. Patients with CS treated w...

Case history: An 85-year-old man with primary hyperparathyroidism, resistant to cinacalcet, presented to hospital with paranoid delusions, weakness, constipation and thirst. His past medical history was of vitamin D deficiency and arthritis of the spine. Regular medications were lansoprazole, senna, and fluticasone nasal spray. He was a never-smoker and had no relevant family history. Neck examination was unremarkable.Investigations: Corrected serum calc...